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Advancements in health and wellness have unlocked doors to a rather important discussion: living longer, healthier lives through science. Lately, there’s hardly anyone who embodies this mission better than Bryan Johnson, the tech entrepreneur turned biohacker aiming to reimagine what aging means.
His documentary, Don’t Die, serves as a guiding light for anyone ready to take control of their health using biohacking tools. Whether it’s through diet, cutting-edge technology, or genetic testing, Johnson’s documentary is a roadmap that offers practical strategies to understand our biology.
But what does this really mean for the average person who most likely doesn’t have access to all the resources upon which Johnson’s strategy relies? How do these biohacking techniques work, and are they truly accessible?
This article unpacks the documentary, highlights the most important practices, and explores how you can integrate simple but powerful strategies—including genetic testing—into your own life.
Bryan Johnson isn't your everyday wellness expert. He’s a serial entrepreneur best known for founding Braintree, a payment solutions company, which he sold for $800 million. Instead of retiring into a life of leisure and luxury, Johnson embarked on an ambitious mission to “engage in the most meaningful work of his life.” He defined the main objective of his mission as preserving and enhancing human health.
Today, Johnson dedicates his life—and millions of dollars annually—to a tightly managed wellness regimen aimed at reversing aging and optimizing his body to perform as efficiently as possible. With a team of medical professionals and researchers, he experiments with cutting-edge science, tests the limits of biohacking, and shares his findings with the world. His goal is simple but inspiring: to help himself and others live not just longer, but better, not compromising the quality of life.
Don’t Die is a documentary that reveals both his personal health regimen and broader insights into the world of biohacking. Johnson’s story combines scientific exploration and personal commitment, making him a distinctive and memorable voice in the conversation about longevity.[1]
Image Source: Standard.co.uk
The documentary Don’t Die serves as a deeply personal exploration of Johnson’s deeply ambitious health pursuits. While many might choose to see it as a how-to guide for biohacking, it’s actually a space to explore the philosophical dilemma about aging.
Throughout the film, Johnson undergoes rigorous wellness practices designed to slow down or even reverse the effects of aging. He employs a team of doctors and scientists to measure everything from hissleep quality to organ health. By sharing both successes and setbacks, Johnson gives viewers a transparent and detailed look at what optimizing health truly entails.
What makes Don’t Die stand out in a sea of typical health documentaries is its focus on cutting-edge science and innovation. It dives into experimental therapies and innovative technologies that erase the lines between science fiction and reality.
From personalized gene editing to advanced biometric monitoring, the documentary is shaped in a way that motivates the audience to think about strategies to live not only longer but better. It also raises important questions about the ethics of innovative practices and breaks the stigma surrounding aging and its inevitability.
According to Johnson, biohacking isn’t a miracle cure but a combination of informed, consistent choices supported by science. It should help you understand and pinpoint what works for your body in order to create and stick to long-term habits.[2]
At its core, Johnson’s approach centers on prevention and optimization. He believes that it is essential to perceive your body as a high-performing machine that requires tailored maintenance. In the sections that follow, we will dissect the key practices emphasized in Don’t Die.[3]
If there’s one biohacking strategy that comes up consistently in Don’t Die, it’s optimizing nutrition. Johnson views food as medicine and supports the idea of a diet optimized to fuel the body by choosing foods that don’t cause inflammation. His approach relies on whole foods, calorie control, and ideal timing.
By closely monitoring his nutrient intake and avoiding heavily processed foods, Johnson aims to reduce stress on his body and support long-term health. For anyone inspired by his example, the lesson is straightforward: What you consume daily has a great impact on your body’s ability to endure over the years.
Johnson heavily emphasizes the critical role sleep plays in overall wellness. The documentary emphasizes how sleep is directly tied to everything from cognitive function to immune health. Johnson uses wearable technology to track his sleep stages, ensuring he gets the much-needed rest his body needs.
He believes that sleep isn’t just something you can “catch up on.” By prioritizing sleep and creating beneficial bedtime routines, you give your body the opportunity to repair and regenerate.
Physical fitness is another pillar of Johnson’s biohacking regimen. But rather than overexerting himself, he focuses on balance. By combining moderate cardio, strength training, and flexibility, he creates a holistic fitness routine that supports heart health, muscle mass, and joint flexibility.
The key element of his foolproof routine is sustainability. While high-intensity workouts might promise groundbreaking and relatively quick results, a thoughtful and consistent exercise routine ensures your body thrives in the long term.
One notable aspect of the documentary is Johnson’s use of supplements and medical interventions to optimize cellular health. From NAD+ boosters to cutting-edge peptides, Johnson explores substances that may delay cellular aging and support mitochondrial health, the energy powerhouse of the body.
Although this area is still developing and requires further research, the core principle is clear. By focusing on the cellular aspect of biology and genetics, you can potentially slow the processes that lead to visible aging, such as declining energy or chronic inflammation.
Biohacking isn’t just about your physical well-being. For Johnson, mental well-being is just as crucial. Don’t Die presents his toolkit for managing emotional health, which includes practices like mindfulness, gratitude journaling, and even psychedelics (but only under professional guidance). This approach is based on growing evidence that unmanaged stress can promote cellular aging and contribute to chronic illness.
According to Don’t Die, it is essential to make time for mental “reset” activities—whether it’s meditation, engaging with nature, or disconnecting from technology.[4]
One of the most intriguing tools featured in Don’t Die is personalized genetic testing. Johnson uses this technology to uncover insights into his body’s predispositions—everything from metabolic tendencies to potential health risks. This data allows him to tailor his biohacking efforts to the unique genetic blueprint, empowering far more effective interventions.
Here’s where genetic testing truly levels the playing field for anyone interested in biohacking. While many of Johnson’s high-tech tools might seem out of reach, genetic testing offers an accessible starting point for optimizing your health.[5] For example, LifeDNA offers genetic tests that analyze your unique DNA to deliver personalized insights into nutrition, fitness, and more.
With this knowledge, you can make informed decisions about your health. Is your metabolism slower than average? Are you predisposed to vitamin deficiencies? Genetic testing helps you answer burning questions, allowing you to invest in strategies tailored to your unique genetic makeup.
Biohacking can be intimidating, especially when presented through the lens of someone like Bryan Johnson, whose resources far exceed what most people can afford. But the principles he presents and stands for—prevention, personalization, and consistency—are universal and bulletproof. By understanding your body’s specific needs through tools like LifeDNA testing, you take a critical first step toward designing a healthier, longer life.
LifeDNA offers a range of cutting-edge tests designed to provide you with insights that are both highly personalized and actionable. From genetic testing that reveals predispositions to certain health conditions to wellness reports detailing how your DNA influences aspects like nutrition, fitness, sleep, and even mood, genetic testing provides you with the data needed to make informed lifestyle decisions.
These comprehensive insights help you understand how your genetics affect nutrient absorption, exercise response, and stress management, allowing you to craft a holistic approach to optimizing your wellness.
Bryan Johnson’s Don’t Die presents the power of biohacking in layman's terms, aiming to transform not just individual lives but the narrative about aging and health. From daily habits like better sleep to advanced practices like genetic testing, the documentary highlights one universal truth: Living longer doesn’t have to mean sacrificing your quality of life.
Whether you’re just starting your wellness journey or looking to take the next step, consider exploring tools for genetic testing. They might not unlock eternal life, but they could help you craft a tailored wellness plan designed just for you.
Discover more about DNA-based personalization and receive tailored reports based on your genetic makeup and find out if your supplement regime is missing an important piece of the puzzle.
Alter, Charlotte. “The Man Who Thinks He Can Live Forever.” Time, 20 Sept. 2023, time.com/6315607/bryan-johnsons-quest-for-immortality/.
Kenigsberg, Ben. ““Don’t Die: The Man Who Wants to Live Forever” Review: Matter over Mind.” The New York Times, 1 Jan. 2025, www.nytimes.com/2025/01/01/movies/dont-die-the-man-who-wants-to-live-forever-review.html.
Radheyan Simonpillai. ““Are We the First Generation That Won’t Die?”: Bryan Johnson on His Controversial Lifestyle.” The Guardian, The Guardian, 2 Jan. 2025, www.theguardian.com/film/2025/jan/02/bryan-johnson-documentary-dont-die-netflix.
Haden, Jeff. “This Billionaire’s “Don’t Die” Strategy Boils down to 5 Basics.” Inc, 9 Jan. 2025, www.inc.com/jeff-haden/this-billionaires-dont-die-strategy-boils-down-to-5-basics/91103931. Accessed 3 Mar. 2025.
Bowers, James. “Biohacking: Medical Promises or Ethical Perils?” Polytechnique Insights, 6 Sept. 2023, www.polytechnique-insights.com/en/columns/health-and-biotech/biohacking-medical-promises-or-ethical-perils/.
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